高永林

1、2003年8月-2010年7月，山东绿叶药物安全评价中心，从事天然药物的药理、毒理学研究工作；

2、2010年8月-至今，烟台大学生命科学学院，从事功能食品的研究开发及安全性评价（毒理学研究）。

功能食品、食品毒理学

1、主持山东省自然科学基金：海带岩藻聚糖硫酸酯抑制缺血所致大鼠神经细胞凋亡的信号通路研究，5.0万元；

2、主持完成山东省自然科学基金“miRNA-27调控环路介导的糖尿病心肌纤维化新机制研究”，6.0万元；

3、主持完成“ARA和DHA遗传、生殖及发育毒性实验研究”等课题，经费60.0万元。

4、主持完成“Rice fiber亚慢性毒性实验研究”等课题，经费20.0万元。

5、主持完成“WR系列天然药物”毒性试验评价及抗肿瘤活性筛选研究，经费12.0万元。

6、开展相关产品GRAS认证的前期评价。

1. Gao YL，Li C, Wang Y, LiuY, Li G, Fan X, Li Y, Tian J, Lee AW. Nonclinicalsafety of astilbin: A 4-week oral toxicity study in rats with genotoxicity,chromosomal aberration, and mammalian micronucleus tests. Food Chem Toxicol.2017;107(Pt A):1-9.

2. Gao YL，Wang YZ, Li YS,Han R, Li CM, Xiao L, Susan Cho, Albert W. Lee, Ma YK, Fang C. Repeatedsub-chronic oral toxicity study of xylooligosaccharides (XOS) in dogs. Regul Toxicol Pharmacol. 2017;86:379-385.

3. Li CM, GaoYL (通讯作者), Wang YZ, Li GS, Fan XC, Li YS,Guo CH, Tao J.Genotoxicity testing of sodium formononetin-3’-sulphonate(Sul-F) by assessing bacterial reverse mutation, chromosomal aberrations andmicronucleus tests. Regul Toxicol Pharmacol. 2017;86:374-378.

4. Gao YL, Wang Y, Wang K,Zhu J, Li G, Tian J, Li C, Wang Z, Li J, Lee AW, Guo C. Acute and a 28-dayrepeated-dose toxicity study of total flavonoids from Clinopodium chinense(Benth.) O. Ktze in mice and rats. Regul ToxicolPharmacol. 2017;91:117-123.

5. Li CM, Han R, Kang L, Wang JP, Gao YL (通讯作者), Li YS, He J, Tian JW. Pirfenidone controlsthe feedback loop of the AT1R/p38 MAPK/renin-angiotensin system axis byregulating liver X receptor-α in myocardial infarction-induced cardiacfibrosis. Sci Rep. 2017;7:40523. doi: 10.1038/srep40523.

6. Li CM, Li GS, Sun CF, Wang XY, Gao YL (通讯作者). A 90-day subchronic toxicity study withSodium formononetin-3'-sulphonate (Sul-F) delivered to dogs via intravenousadministration. Regul Toxicol Pharmacol. 2016;77:87-92.

7. Gao YL, Kang L, Li CM,Wang XY, Sun CF, Li QZ, Liu R, Wang JP. Resveratrol amelioratesdiabetes-induced cardiac dysfunction through AT1R-ERK/p38 MAPK signalingpathway. Cardiovasc Toxicol. 2016;16(2):130-7.

8. Li GS, Yang M, Hao X, Li CM, Gao YL (通讯作者), Tao J.  Acutetoxicity of sodium formononetin-3'-sulphonate (Sul-F) in Sprague- Dawley ratsand Beagle dogs. Regul Toxicol Pharmacol. 2015;73(2):629-33.

9. Gao YL, Li CM, Kang L,Hang B, Yan MJ, Li SJ, Jin HZ, Lee AW, Susan SA. Subchronic toxicity study,preceded by an in utero exposure phase, with refined arachidonic acid-rich oil(RAO) derived from Mortierella alpine XM027 in rats. Regul Toxicol Pharmacol.2014;70(3):696-703.

10. Gao YL, Shen JY, Yin,JG,Li CM, Fu CY, Susan Cho. A subchronic dietary toxicity study of rice hull fiberin rats. Food Chem. Toxicol.2013;51:137-142.

11. Gao YL, Li CM, Yin JG , ShenJY, Wang HT, Wu YZ, Jin HZ. 2012. Fucoidan, a sulfated polysaccharide frombrown algae, improves cognitive impairment induced by infusion of amyloid-βpeptide in rats. Environ Toxicol Phar. 2012, 33(2):304-311.

12. Gao YL, Dong CH, Yin JG,Shen JY, Tian JW, Li CM. 2012. Neuroprotective effect of fucoidan on H₂O₂-inducedapoptosis in PC12 Cells via activation of PI3K/Akt Pathway. Cell Mol Neurobiol.2012, 32(4):523-529.

13. Gao YL, Zhang SM, Li CM,Xiao L, Shen JY, Yin JG. Acute and subchronic toxicity of Xylo-oligosaccharidein mice and rats. Toxicol. Mech. Methods 2012;22(8):605-610.

14. Gao YL, Jiang WL, DongCH, Li CM, Fu XJ, Li M, Tian JW, Jin HZ, Shen JY. 2011. Anti-inflammatoryeffects of sophocarpine in LPS-induced RAW 264.7 cells via NF-κB and MAPKs signalingpathways. Toxicol. in Vitro.2012;26(1):1-6.

15. Li CM, GaoYL (通讯作者), Tian JW, Xing YL, Zhu HB, Shen JY.Long-term oral Asperosaponin VI attenuates cardiac dysfunction, myocardialfibrosis in a rat model of chronic myocardial infarction. Food Chem Toxicol. 2012;50(5):1432-8.

烟台大学青年学术骨干

中国毒理学会会员

山东省毒理学会理事

山东省食品科学技术学会高级会员

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