姓名：孟庆国
学位：博士
毕业院校及专业：中国协和医科大学，微生物与生化药学专业
职称：教授
主讲课程：有机化学、有机化学实验
研究方向：天然产物结构修饰与抗炎、抗肿瘤活性研究
教学、科研项目：
1、 2015.01-2018.12：主持并完成国家自然科学基金（系列C20差向异构ocotillol型皂苷的合成、心肌缺血/再灌注损伤保护作用构效关系、ADME与作用机制研究，No. 81473104），已结题
2、2011.01-2011.12：主持并完成国家自然科学基金（新型氮唑类抗真菌化合物的设计合成与构效关系研究，No. 81072534），已结题；
3、2008.01-2010.12：主持并完成山东省自然科学基金：（喃型人参皂苷衍生物对急性心肌缺血损伤保护作用的研究），Y2007C138，已结题
4、 2012.07-2015.07：主持并完成山东省自然科学基金课题一项（Ocotillol型差向异构体的制备、立体选择性吸收机理及代谢研究），ZR2012HM036，已结题
5、2008.01-2010.12：主持并完成山东省高等学校科研计划项目（人参皂苷衍生物对急性心肌缺血损伤的保护作用研究），J07WE26，已结题
6、 2020.01.01-2022.12.30：主持并完成烟台市科技创新发展计划项目，以熊果酸为先导的iNOS小分子抑制剂的发现与开发（校地合作），项目编号，2020XDRH105，已结题
7、 2016.10-2019.10：主持并完成山东省研究生教育创新计划项目（药学硕士（工业药学方向）“双导师制”培养与工业药学实践模式探究），山东省人民政府学位委员会，山东省教育厅，SDYY16132，已结题
主要论文、专著与专利：
1.Panpan Weia,ǂ,Qin Luoa, ǂ, Yun Houb, Fenglan Zhaoa, Feng Lia, *,Qingguo Menga,*. Houttuynia Cordata Thunb.: A comprehensive review of traditional applications, phytochemistry, pharmacology and safety. Phytomedicine, 2024, 123, 155195. doi.org/10.1016/j.phymed.2023.155195
2.Juan Zhang, Zhen Wang, Conghao Gai, Fan Yang, Xiaoqing Yun, Boye Jiang, Yan Zou, Qingguo Meng*, Qingjie Zhao*, Xiaoyun Chai*. Design, synthesis, evaluation and optimization of novel azole analogues as potent antifungal agents. Bioorganic Medicinal Chemistry, 2024, 97: 117543.doi.org/10.1016/j.bmc.2023.117543
3.Shengnan Zhanga, Taiqiang Ye（共同一作）, Yibin Liu, Guige Hou, Qibao Wang, Fenglan Zhao, Feng Li,* and Qingguo Meng*. Research Advances in Clinical Applications, Anticancer Mechanism, Total Chemical Synthesis, Semi-Synthesis and Biosynthesis of Paclitaxel. Molecules, 2023, 28, 7517. doi.org/10.3390/molecules28227517
4.Juan, Zhang, Siyu Tao, Guige Hou, Fenglan Zhao, Qingguo Meng*, Shenpeng Tan*. Phytochemistry, nutritional composition, health benefits and future prospects ofPassiflora: A review. Food Chemistry, 2023, 428, 136825.https://doi.org/10.1016/j.foodchem.2023.136825
5.JZhen Wang, Shengnan Zhao, Siyu Tao, Guige Hou, Fenglan Zhao, Shenpeng Tan* and Qingguo Meng*.Dioscoreaspp.: Bioactive Compounds and Potential for the Treatment of Inflammatory and Metabolic Diseases. Molecules, 2023, 2023, 28, 2878. https://doi.org/10.3390/molecules28062878
6.Juan Zhang, Ruolin Zhao, Guige Hou*, Qibao Wang, Fenglan Zhao, Zhi Liu* and Qingguo Meng*. Stereoscopic Differences in the Identification, Bioactivity, and Metabolism of C-20 and C-24 Epimeric Ginseng Saponins. Mini-Reviews in Medicinal Chemistry, 2023, 23 (7): 804-820. DOI:10.2174/1389557522666221012095258
7.Mingzhu Luana,b, Xiaofan Zhangb, Yang Yangc, Qingguo Mengb,*, Guige Houa,*. Anti-inflammatory activity of fluorine-substituted benzo[h] quinazoline-2-amine derivatives as NF-κB inhibitors. Bioorganic Chemistry, 2023, 132, 106360. doi.org/10.1016/j.bioorg.2023.106360
8.Zhen Wang, Fenglan Zhao, Panpan Wei, Xiaoyun Chai2*, Guige Hou3*, Qingguo Meng1*. Sea buckthorn (Hippophae rhamnoidesL.): A comprehensive review of phytochemistry, biological activities and food applications. 2022, Frontiers in Nutrition, 2022,9,1036295.
9.Juan Zhang1, Xiaoyun Chai2,*, Fenglan Zhao1, Guige Hou3and Qingguo Meng1,*. Food Applications and Potential Health Benefits of Hawthorn. Foods, 2022, 11, 2861.https://doi.org/10.3390/foods11182861
10.Panpan Wei, Fenglan Zhao, Zhen Wang, Qibao Wang, Xiaoyun Chai2*, Guige Hou3*and Qingguo Meng1*. Sesame (Sesamum IndicumL.): a comprehensive review of nutritional value, phytochemical composition, health benefits, development of food, and industrial applications. Nutrients, 2022, 14, 4709. doi.org/10.3390/nu14194079
11.Shengnan Zhanga, Xiaoyun Chaib,*, Guige Houc, Fenglan Zhaoa, Qingguo Menga,**.Platycodon grandiflorum(Jacq.) A. DC.: A review of phytochemistry, pharmacology, toxicology and traditional use. Phytomedicine, 2022, 106: 154422. doi.org/10.1016/j.phymed.2022.154422
12.Mingzhu Luan‡,1, Yaoyao Xu‡,1, Xiaofan Zhang1, Dalei Li1, Mengjun Yan2, Guige Hou3, Qingguo Meng*,1, Feng Zhao**,1& Fenglan Zhao1. Design and synthesis of novel aza-ursolic acid derivatives: in vitro cytotoxicity and nitric oxide release inhibitory activity. Future Med. Chem., 2022, 14 (8): 535-555.
13.Sheng-Nan Zhanga,1, Xiao-Dong Mua,1, Xiao-Fan Zhanga,1, Ming-Zhu Luana, Guang-Qun Maa, Wei Lid, Qing-Guo Menga,*, Xiao-Yun Chaib,*, Gui-Ge Houc,*. Synthesis, biological evaluation and molecular docking studies of novel diosgenin derivatives as anti-inflammatory agents. Bioorganic Chemistry, 2022, 127, 105908.
14.Xiao-FanZhang,Ming-Zhu Luan,Wei-BinYan, Feng-Lan Zhao, Yun Hou,Gui-Ge Houb,**, Qing-Guo Menga,*. Anti-neuroinflammatory effects ofnovel 3,4-dihydronaphthalen-1(2H)-one derivatives in lipopolysaccharide-stimulated BV2 microglial cells. European Journal of Medicinal Chemistry, 2022, 235: 114322.
15.Guangqun Ma, Xiaoyun Chai2,*, Guige Hou, Fenglan Zhao, Qingguo Meng1*. Photochemistry, bioactivities and future prospects of mulberry leaves: A review. Food Chemistry, 2022, 372, 131335.
16.Kewei Sun, Zhonghao Sun, Fenglan Zhao, Guangzhi Shan* & Qingguo Meng*. Recent advances in research of colchicine binding site inhibitors and their interaction modes with tubulin. Future Medicinal Chemistry, 2021, 13(9): 839-858.https://doi.org/10.4155/fmc-2020-0376
17.孟庆国，王洪波，赵风兰，王文智，雷蕾，刘娟，杨静静，王朝明，刘智，王嘉珍。一种具有抗肿瘤活性的熊果酸衍生物及其制备方法。专利号：ZL 201710341785.2；申请日2017.05.16，授权公告日：2019.04.19
18.孟庆国，赵烽，王文智，张倩，李惠香，刘娟、杨静静、王朝明，刘智，王嘉珍。一种具有抗炎活性的熊果酸衍生物及其制备方法和用途。专利号：ZL 201710341813.0。申请日2017.05.16，授权公告日：2019.07.30
19.孟庆国，王洪波，赵风兰，徐阳荣，雷蕾，杨静静，张建强，刘智。齐墩果酸四氮唑衍生物及其制备方法和用途。专利号：ZL 201710341725.0。申请日2017.05.16，授权公告日：2019.07.30
20.发明人：孟庆国，宋萍萍，王文智，张建强，王朝明，刘智，邓建强，王嘉珍，翁卫钊，何萌。一种ocotillol型化合物作为农业杀菌剂的新用途，专利号：ZL 201810152570.0，授权公告日：2020.10.23。申请日2018.02.16
21.孟庆国，赵风兰，张德武，赵若琳，刘智，赵建元，岑山，王嘉珍，邓建强，牟晓懂，王晓慧，刘丽，栾明珠，张晓凡，孙可微，唐航军，马颖。含氮杂环甘草次酸衍生物及其制备方法和抗甲型流感病毒应用，专利号：ZL 201911177679.0，申请日期：2019.11.25；申请日：2019.11.25，授权日：2021.06.11
22.孟庆国，赵烽，赵风兰，王嘉珍，张庆然，栾明珠，张晓凡，赵若琳，宗明月，刘丽，王璐琼，牟晓懂，王晓慧，孙可微。低毒性、抗炎熊果酸衍生物及其制备方法和应用，专利号：ZL 202010517913.6，申请日：2020.06.09，授权公告日：2022.03.04
23.孟庆国，王洪波，赵风兰，邓建强，刘书琪，刘丽，王嘉珍，赵若琳，牟晓懂，张晓凡，栾明珠，王晓慧，孙可微，唐航军。氮杂20(R)-人参二醇衍生物及其抗肿瘤应用，专利号：ZL 202010330822.1，发明人：申请号：202010330822.1，申请日：2020.04.23，授权公告日：2022.11.25